Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease
Identifieur interne : 004721 ( Main/Exploration ); précédent : 004720; suivant : 004722Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease
Auteurs : Marie-Paule Muriel [France] ; Yves Agid [France] ; Etienne Hirsch [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Basal Ganglia (ultrastructure), Brain (pathology), Case-Control Studies, Caudate Nucleus (chemistry), Caudate Nucleus (ultrastructure), Corpus Striatum (ultrastructure), Corpus striatum, D1 Dopamine receptor, Human, Humans, Immunohistochemistry, In Vitro Techniques, Microscopy, Electron, Middle Aged, Neural Pathways, Neuronal Plasticity, Neurons, Afferent (ultrastructure), Parkinson, Parkinson Disease (pathology), Parkinson disease, Pathophysiology, Postmortem, Receptors, Dopamine D1 (chemistry), Synapses (ultrastructure), Synaptic plasticity, basal ganglia, dopamine receptor, plasticity.
- MESH :
- chemical , chemistry : Receptors, Dopamine D1.
- chemistry : Caudate Nucleus.
- pathology : Brain, Parkinson Disease.
- ultrastructure : Basal Ganglia, Caudate Nucleus, Corpus Striatum, Neurons, Afferent, Synapses.
- Aged, Aged, 80 and over, Case-Control Studies, Humans, Immunohistochemistry, In Vitro Techniques, Microscopy, Electron, Middle Aged, Neural Pathways, Neuronal Plasticity.
Abstract
The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing D1 dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non‐D1R spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with D1R‐bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1103
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-05">2001-05</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="435">435</biblScope><biblScope unit="page" to="441">441</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F08BA412500E87376349EF77A6BFA0B59E5FF1DD</idno><idno type="DOI">10.1002/mds.1103</idno><idno type="ArticleID">MDS1103</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Basal Ganglia (ultrastructure)</term><term>Brain (pathology)</term><term>Case-Control Studies</term><term>Caudate Nucleus (chemistry)</term><term>Caudate Nucleus (ultrastructure)</term><term>Corpus Striatum (ultrastructure)</term><term>Corpus striatum</term><term>D1 Dopamine receptor</term><term>Human</term><term>Humans</term><term>Immunohistochemistry</term><term>In Vitro Techniques</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Neural Pathways</term><term>Neuronal Plasticity</term><term>Neurons, Afferent (ultrastructure)</term><term>Parkinson</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Postmortem</term><term>Receptors, Dopamine D1 (chemistry)</term><term>Synapses (ultrastructure)</term><term>Synaptic plasticity</term><term>basal ganglia</term><term>dopamine receptor</term><term>plasticity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Caudate Nucleus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Basal Ganglia</term><term>Caudate Nucleus</term><term>Corpus Striatum</term><term>Neurons, Afferent</term><term>Synapses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Humans</term><term>Immunohistochemistry</term><term>In Vitro Techniques</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Neural Pathways</term><term>Neuronal Plasticity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Corps strié</term><term>Homme</term><term>Immunohistochimie</term><term>Parkinson maladie</term><term>Physiopathologie</term><term>Plasticité synaptique</term><term>Postmortem</term><term>Récepteur dopaminergique D1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing D1 dopamine receptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects and PD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with D1R dendritic spines was observed, whereas no change in the number of perforated synapses on non‐D1R spines was observed. The change in the number of perforated synapses on D1R dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with D1R‐bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Muriel, Marie Aule" sort="Muriel, Marie Aule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name></noRegion><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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